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In skeletal muscle, STAT5a/b transcription factors are critical for normal postnatal growth, whole-animal glucose homeostasis, and local IGF-1 production. These observations have led us to hypothesize that STAT5a/b are critical for maintenance of normal muscle mass and function. To investigate thi...
ORGANISM(S): Mus musculus 
Host genes interacting with ankyrin repeat-containing protein, p200, in Ehrlichia chaffeensis-infected monocytes. Chromatin immunoprecipitation (ChIP) together with microarray (chip) analysis demonstrated enrichment of relatively small subset (n=456) of host cell genes associated with molecular and ...
ORGANISM(S): Homo sapiens 
Iron is essential for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated. Serum iron is bound to transferrin and primarily enters erythroid cells via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythroc...
ORGANISM(S): Mus musculus 
Differential proteome profiling of IBD serum exosomes to find corresponding regulatory protein cargoes of serum exosomes in IBD progress. Exosomal proteins were extracted using SDT buffer lysis (4% SDS, 100mM Tris HCl, 1mM DTT, pH7.6), and the protein concentration was determined using the BCA prote...
ORGANISM(S): Homo Sapiens 
2023-07-07 | PXD043594 |
Sugar beet M14 line is a diploid cultivated sugar beet (Beta vulgaris L.) that carries a monosomic addition of chromosome 9 from the wild white-flowered beet (B. corolliflora Zoss.), developed through distant hybridization. It exhibits enhanced salt and drought tolerance compared to the diploid cult...
ORGANISM(S): Beta Vulgaris Subsp. Vulgaris 
2025-12-18 | PXD072192 |
Label-free absolute quantitative proteomics is commonly used for absolute quantification of the proteome or specific proteins of interest in various biological samples. Current label-free absolute protein quantification (APQ) methods determine MS1 intensities, MS2 spectral counts or intensities to a...
ORGANISM(S): Homo sapiens (Human) 
2019-03-20 | PXD010912 | Pride
Aging was long assumed to be a passive and stochastic process caused by random damage accumulation, however,such theories fail to explain the program-like features of the aging process. Measuring the aging process in C. elegans at individual level provides an opportunity to analyze both the programm...
ORGANISM(S): Caenorhabditis elegans 
2023-11-14 | PXD039330 | Pride
Background: Previous expression quantitative trait loci (eQTL) studies have identified thousands of genetic variants to be associated with gene expression at the mRNA level in the human liver. However, protein expression often correlates poorly with mRNA levels. Thus, protein quantitative trait loci...
ORGANISM(S): Homo sapiens (Human) 
2020-07-21 | PXD019169 | Pride
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