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Aging is a complex biological process influenced by genetic factors, environmental conditions, and interactions between organisms and their associated microbes. The budding yeast Saccharomyces cerevisiae and the fruit fly Drosophila melanogaster provide complementary model systems for investigati...

2026-09-04 | MTBLS15555 | MetaboLights
Endometrial cancer (EC) is one of the most common gynecological cancers. Finding biomarkers of EC can support its diagnosis in a non- or minimally-invasive way. In this work, we integrated metabolomics and proteomics for the analysis of multiple types of biosamples to gain a more comprehensive view ...
2022-03-28 | MTBLS3935 | MetaboLights
Our data provided a genome-wide DNA methylation landscape of human early development embryos, including human MII oocytes, sperm, zygotes, 2-cell to 8-cell embryos, morula, blastocyst and postimplantation embryos at single base resolution. In total, 44 samples including biological and technical repl...
ORGANISM(S): Homo sapiens 
5-Hydroxymethylcytosine (hmC) is particularly abundant in mammalian brains with yetto be revealed functions. Here, we present genome-wide and single-base-resolutionmaps of hmC and mC in the human brain. We demonstrated that hmCs increasemarkedly from the fetal to the adult stage, and in the adult br...
ORGANISM(S): Homo sapiens 
we present an aggregation-induced emission (AIE) - bacteria hybrid bionic robot to address the above issues. This bionic robot is composed of a multifunctional AIE molecule, INX-2 and Escherichia coli Nissle 1917 (EcN), i.e. EcN@INX-2. The robot is characterized by NIR-II fluorescence emission with ...
ORGANISM(S): Mus Musculus 
2024-10-18 | PXD056926 |
Metabolic regulation of cytoskeleton functions by HDAC6-catalyzed α-tubulin lactylation
ORGANISM(S): Mus Musculus 
2024-09-12 | PXD055797 |
Although the landscape of epigenomic and transcriptomic regulation during human pre-implantation development has been depicted by applying single-cell sequencing, the investigation of embryonic proteome is almost unrevealed due to the insufficient input quantity from precious human embryonic samples...
ORGANISM(S): Homo Sapiens 
2021-04-20 | PXD024267 |
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