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TranscriptomicsDifferential early pathogenic changes in human ileal gene expression in Crohn's disease and ulcerative colitis
The aim of this study is to identify early pathogenic changes in ileal gene expression that precede the development of macroscopic disease in inflammatory bowel diseases (IBDs). We focused on two IBD phenotypes that were unlikely to overlap: 1) ileal Crohn’s disease (CD) patients undergoing initi...
ORGANISM(S): Homo sapiens 
2010-09-26 | E-GEOD-24287 | biostudies-arrayexpress
ProteomicsArabidopsis γ-H2A.X-INTERACTING PROTEIN participates in DNA damage response and safeguards chromatin stability
We extracted proteins from WT and xip for phospho-peptide enrichment and employed a quantitative phospho-proteomics approach to systematically survey the relevant modification changes.
ORGANISM(S): Arabidopsis Thaliana 
2022-09-28 | PXD037072 |
UnknownAntitumor activity of TY-011 against gastric cancer by inhibiting Aurora A, Aurora B and VEGFR2 kinases.
Not available
S-EPMC5124248 | biostudies-literature
MetabolomicsMulti-omics analysis of Arabidopsis leaves upon infection by necrotrophic pathogen Botrytis cinerea

Botrytis cinerea is a necrotrophic pathogen that induces host cell death, causing substantial economic losses in agriculture. In this study, we show that functional depletion of INOSITOL AUXOTROPHY 80 (INO80), a nuclear factor involved in local chromatin remodeling, reduces the susceptibility of ...

2026-03-09 | MTBLS12467 | MetaboLights
ProteomicsHSPA1A and DNAJB1 regulate NELF condensate reversibility to safeguard transcriptional recovery under heat stress
The negative elongation factor (NELF) is essential in establishing RNA Polymerase II (Pol II) pausing at promoter-proximal regions, providing a key regulatory checkpoint for precise gene expression control. In response to heat shock (HS) stress, NELF has been observed to form nuclear condensates, bu...
ORGANISM(S): Homo Sapiens 
2025-05-21 | PXD064175 |
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
2024-10-03 | PXD056593 |
UnknownRobust estimation of bacterial cell count from optical density.
Not available
S-EPMC7499192 | biostudies-literature
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