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MetabolomicsAbsence of tmRNA Increases the Persistence to Cefotaxime and the Intercellular Accumulation of Metabolite GlcNAc in Aeromonas veronii
Bacterial persisters are a small proportion of phenotypically heterogeneous variants with the transient capability to survive in high concentrations of antibiotics, causing recurrent infections in both human and aquatic animals. Transfer-messenger RNA (tmRNA), which was encoded by the ssrA ge...
2021-10-18 | MTBLS1182 | MetaboLights
TranscriptomicsA genomic approach to bud mutation in sweet orange (Citrus sinensis L. Osbeck) fruit
Bud mutations arise often in citrus. The selection of mutants is one of the most important breeding methods in citrus. However, the molecular bases of bud mutation have rarely been studied. To identify the potential important or novel genes involved in bud mutation, different transcriptomic techniqu...
ORGANISM(S): Citrus sinensis 
2009-03-09 | E-GEOD-10729 | biostudies-arrayexpress
ProteomicsMULTI-TARGETED FLAVONOID INHIBITION OF THE PATHOGENIC BACTERIUM STAPHYLOCOCCUS AUREUS: A Proteomic Characterization
Growth inhibition of the pathogen Staphylococcus aureus with currently available antibiotics is problematic in part due to bacterial biofilm protection. While Although the recently characterized natural products, including 3´,4´,5-trihydroxy-6,7-dimethoxy-flavone [1], 3´,4´,5,6,7-pentahydroxy-flavon...
ORGANISM(S): Staphylococcus aureus 
2017-05-30 | PXD006030 | Pride
Antibacterial flavonoids  lc-ms/ms proteomics  multi-targeted bacterial inhibition Staphylococcus aureus 
ProteomicsEnhanced Quantitative LC-MS/MS Analysis of N-linked Glycans Derived from Glycoproteins Using Sodium Deoxycholate Detergent
Protein glycosylation is a common protein post-translational modification (PTM) in living organisms and has been shown to associate with multiple diseases, and thus may potentially be a biomarker of such diseases. Efficient protein/glycoprotein extraction is a key step in the preparation of N-glycan...
ORGANISM(S): Homo sapiens (Human) 
2018-05-16 | PXD008687 | Pride
Acidic labile detergent Detergent removal Lc-ms/ms sample preparation N-glycomics Sodium deoxycholate 
TranscriptomicsRNA Polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA Polymerase II
Release of promoter-proximal paused RNA polymerase II (Pol II) during early elongation is a critical step in transcriptional regulation in metazoan cells. Paused Pol II release is thought to require the kinase activity of cyclin-dependent kinase 9 (CDK9) for the phosphorylation of DRB sensitivity-in...
ORGANISM(S): Homo sapiens 
2015-12-11 | E-GEOD-62171 | biostudies-arrayexpress
ProteomicsProteomic raw data for ctrl HRECs, CAPSL knockdown HRECs, and CAPSL overexpression HRECs
The purpose of this project is to explore the changes in signaling pathways after CAPSL knockdown and overexpression, and to identify potential downstream target genes of CAPSL along with the signaling pathways they are involved in. Ultimately elucidating the molecular mechanisms underlying CAPSL pa...
ORGANISM(S): Homo sapiens (Human) 
2024-09-04 | PXD051696 | Pride
Hrecs  capsl  knockdown  overexpression 
ProteomicsComparative Membrane Proteomics Analyses of Breast Cancer Cell Lines to Understand the Molecular Mechanism of Breast Cancer Brain Metastasis
Breast cancer is the leading type of cancer in women. Breast cancer brain metastasis is considered as an essential issue in breast cancer patients. Membrane proteins play important roles in breast cancer brain metastasis that contributes to the cell adhesion and penetration of blood-brain barrier. T...
ORGANISM(S): Homo sapiens (Human) 
2017-05-23 | PXD005719 | Pride
Proteomics Breast cancer brain metastasis Membrane enrichment Differential expression analysis Lc-ms/ms 
TranscriptomicsGene expression in Maize root region 1 at low water potential
Previous work showed that the maize primary root adapts to low water potential (-1.6 MPa) by maintaining longitudinal expansion in the apical 3 mm (region 1), whereas in the adjacent 4 mm (region 2) longitudinal expansion reaches a maximum in well-watered roots but is progressively inhibited at low ...
ORGANISM(S): Zea mays 
2010-05-26 | E-GEOD-9341 | biostudies-arrayexpress
ProteomicsIntegrated Transcriptomics, Proteomics and Glycomics for a Deeper Insight of the Mechanism of Breast Cancer Brain Metastasis: Emphasizing on Glycosylation
Breast cancer brain metastasis has been recognized as one of the central issues in breast cancer research. Elucidation of the process and pathway that mediate this step is expected to provide important clues for a better understanding of breast cancer metastasis. Increasing evidence suggests that th...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD010506 | Pride
Integrative omics analysis Glycomics Transcriptomics Proteomics Breast cancer brain metastasis 
ProteomicsIntact-cell thermal PISA-MS target-engagement profiling of M5717 in Plasmodium falciparum
Here we demonstrate eEF1-alpha and eEF2 stabilisation by M5717 in the intact-cell P. falciparum-infected red blood cells, using thermal Proteome Integral Solubility Alteration (Thermal PISA) assay coupled with Data Independent Acquisition Mass Spectrometry (DIA-MS).
ORGANISM(S): Plasmodium (plasmodium) 
2026-02-17 | PXD059612 | JPOST Repository
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