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MetabolomicsLC-MS/MS targeted analysis of ferroptosis-associated phospholipid peroxidation in KIF11-depleted HRECs

Human retinal vascular endothelial cells (HRECs) were transfected with lentivirus encoding either KIF11-targeting shRNA or a non-targeting control. KIF11-depleted and control cells were then subjected to lipid extraction followed by LC–MS/MS–based targeted analysis of ferroptosis-associated phosp...

2026-02-13 | MTBLS12912 | MetaboLights
ProteomicsProteomic raw data for ctrl HRECs, CAPSL knockdown HRECs, and CAPSL overexpression HRECs
The purpose of this project is to explore the changes in signaling pathways after CAPSL knockdown and overexpression, and to identify potential downstream target genes of CAPSL along with the signaling pathways they are involved in. Ultimately elucidating the molecular mechanisms underlying CAPSL pa...
ORGANISM(S): Homo sapiens (Human) 
2024-09-04 | PXD051696 | Pride
Hrecs  capsl  knockdown  overexpression 
GenomicsTranscriptome profiling identified a 3-lncRNA regulatory network in transthyretin against glucose induced hRECs dysfunction
Transcriptome profiling identified a 3-lncRNA regulatory network in transthyretin against glucose induced hRECs dysfunction
PRJNA481517 | ENA
GenomicsDimethyl Fumarate (DMFu) as an anti-angiogenic agent in VEGF-treated human microvascular retinal endothelial cells (HRECs).
Dimethyl Fumarate (DMFu) as an anti-angiogenic agent in VEGF-treated human microvascular retinal endothelial cells (HRECs).
PRJNA1204363 | ENA
TranscriptomicsRNA-SEQ of HRECs depleted with Norrin/beta-catenin signaling components or KIF11 or PRDX1
We performed RNA-Seq on human microvascular endothelial cells (HRECs) with lentivirus-mediated knockdown of CTNNB1, LRP5, FZD4, TSPAN12, KIF11, and PRDX1. This dataset includes the gene expression profiles that reveal the specific gene expression changes that occur in HRECs following the knockdown o...
ORGANISM(S): Homo sapiens 
2026-02-13 | GSE306946 | GEO
TranscriptomicsDimethyl Fumarate (DMFu) as an anti-angiogenic agent in VEGF-treated human microvascular retinal endothelial cells (HRECs).
Vascular endothelial growth factor (VEGF) is a key driver of retinal and choroidal angiogenesis in wet age-related macular degeneration (nAMD). The present study investigated the impact of dimethyl fumarate (DMFu), a novel nAMD therapeutic candidate, on the transcriptomic profile of VEGF-treated pri...
ORGANISM(S): Homo sapiens 
2025-09-03 | GSE285562 | GEO
Proteomicsproteomics conducted in control and KIF11-depleted HRECs
This dataset includes raw data from proteomics conducted in control and KIF11-depleted HRECs.
ORGANISM(S): Homo sapiens (Human) 
2026-02-13 | PXD074452 | Pride
Endothelial cells Kif11 Human Retina 
TranscriptomicsTranscriptome profiling identified a 3-lncRNA regulatory network in transthyretin against glucose induced hRECs dysfunction
Transcriptome of human retinal endothelial cells (hRECs) treated with low glucose (LG), high glucose (HG) or high glucose with 4 uM TTR (HG+TTR) were conducted. Differentially expressed lncRNAs, mRNAs and TTR related lncRNAs and mRNA were acquired for further analysis. Functional annotation and enri...
ORGANISM(S): Homo sapiens 
2018-07-18 | GSE117238 | GEO
ProteomicsPlacental Growth Factor Regulates the Pentose Phosphate Pathway and Antioxidant Defense Systems in Human Retinal Endothelial Cells
The molecular mechanisms whereby placental growth factor (PlGF) mediates its effects in nonproliferative diabetic retinopathy (DR) are unknown. To better understand the role of PlGF in DR, we used tandem mass tags (TMT)-labeled quantitative proteomics to human retinal endothelial cells (HRECs), tre...
ORGANISM(S): Homo sapiens (Human) 
2020-03-17 | PXD017195 | Pride
Tmt Prdx6 Kegg Plgf Ppp 
UnknownUpregulation of CKIP-1 inhibits high-glucose induced inflammation and oxidative stress in HRECs and attenuates diabetic retinopathy by modulating Nrf2/ARE signaling pathway: an in vitro study.
Not available
S-EPMC6708125 | biostudies-literature
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