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TranscriptomicsExpression data from Th2 cell of ECM1 KO mice vs WT mice
CD4+ helper T cells are critical for immunological response. Th2 cells, a subset of CD4+ helper T cells, are responsible for asthma and other immune diseases. We found a Th2 secreted protein, ExtraCellular Matrix protein 1 (ECM1), which is highly induced by classic IL-4 signaling pathway during help...
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-19707 | biostudies-arrayexpress
GenomicsMediator promotes CENP-A incorporation at fission yeast centromeres [ChIP-seq]
At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A/Cnp1, which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (...
ORGANISM(S): Schizosaccharomyces pombe 
2012-11-06 | E-GEOD-35524 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNAseq of Human T lymphocyte derived from H7N9 infected patients
Comparing transcriptomes of CD8 T cells derived from a fatal H7N9 influenza infection with those derived from a patient that survived the infection. Specifically, CD38+ HLA-DR+ cells were sorted by flow cytometry at different sampling time-points, and the transcriptome was analysed using Smart-seq2.
ORGANISM(S): Homo sapiens 
2018-01-30 | E-MTAB-6379 | biostudies-arrayexpress
UnknownValidation of the BD FACSPresto system for the measurement of CD4 T-lymphocytes and hemoglobin concentration in HIV-negative and HIV-positive subjects.
Not available
S-EPMC7658244 | biostudies-literature
TranscriptomicsTranscription profiling of human dendritic cells treated with lipopolysaccharides and R848
Toll-like receptor (TLR) signalling activation by pathogens is critical to the induction of immune responses, and demands tight regulation. Chemokine ligand 2 (CCL2) secretion triggered by TLR4 or TLR8 engagement is strongly inhibited upon simultaneous activation of both TLRs in human monocyte-deriv...
ORGANISM(S): Homo sapiens 
2009-05-22 | E-MEXP-2183 | biostudies-arrayexpress
UnknownAssociation of Fcγ receptor IIB polymorphism with cryptococcal meningitis in HIV-uninfected Chinese patients.
Not available
S-EPMC3411792 | biostudies-literature
TranscriptomicsTesticular germ cell tumor susceptibility genes from the consomic 129.MOLF-Chr19 mouse strain
Chromosome substitution strains (CSS or consomic strains) are useful for mapping phenotypes to chromosomes. However, huge efforts are needed to identify the gene(s) responsible for the phenotype in the complex context of the chromosome. Here, we report the identification of candidate disease genes...
ORGANISM(S): Mus musculus 
2009-01-13 | E-GEOD-14354 | biostudies-arrayexpress
UnknownComparative genomics profiling revealed multi-stress responsive roles of the CC-NBS-LRR genes in three mango cultivars.
Not available
S-EPMC10642748 | biostudies-literature
TranscriptomicsMicroRNA profiling of adult male zebrafish exposed to 17-beta estradiol (E2) for 0, 1, 4. 12 and 24 hours
Microarrays displaying zebrafish miRNAs specific probes were hybridized using RNA samples originating from whole body homogenates of male zebrafish exposed to 17-beta estradiol (E2) for 0, 1, 4. 12 and 24 hours. 0 hr fish No. 40, 41, 42. 1hr fish No. 8, 10, 11. 4hr fish No. 19, 20, 23. 12hr fish N...
ORGANISM(S): Danio rerio 
2007-12-30 | E-MEXP-1147 | biostudies-arrayexpress
TranscriptomicsSequencing of murine corticotrophs from male and female POMC-GFP mice.
Stress-related illness represents a major burden on health and society. Understanding the molecular mechanisms underlying stress responses is an important step to understand these diseases, and design treatments. Sexual dimorphism in stress responses have been extensively reported, with depression a...
ORGANISM(S): Mus musculus 
2023-05-03 | E-MTAB-12885 | biostudies-arrayexpress
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