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MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
GenomicsThe inactive X chromosome adopts a unique three-dimensional conformation that is dependent on Xist RNA.
3D-topology of DNA in the cell nucleus provides a level of transcription regulation beyond the sequence of the linear DNA. To study the relationship between transcriptional activity and spatial environment of a gene, we have used allele-specific 4C-technology to produce high-resolution topology maps...
ORGANISM(S): Mus musculus 
2011-06-24 | E-GEOD-29509 | biostudies-arrayexpress
MetabolomicsMetabolomics Analysis Reveals Tissue-Specific Metabolite Compositions in Leaf Blade and Traps of Carnivorous Nepenthes Plants
Nepenthes is a genus of carnivorous plants that evolved a pitfall trap, the pitcher, to catch and digest insect prey to obtain additional nutrients. Each pitcher is part of the whole leaf, together with a leaf blade. These two completely different parts of the same organ were studied separately in a...
2020-07-10 | MTBLS1783 | MetaboLights
TranscriptomicsRNA Seq analysis of Mefs Isolated from STC1+/+ and STC1-/- mice
Evaluation of X-linked gene expression in MEFs isolated from STC1 wild type and knock out mice X chromosome inactivation (XCI) is initiated in cis by the Xist RNA, which coats the inactive X chromosome (Xi) from which it is produced. We performed a large-scale RNA interference screen to identify tr...
ORGANISM(S): Mus musculus 
2014-07-29 | E-GEOD-47395 | biostudies-arrayexpress
TranscriptomicsIdentifying crossover locations in Arabidopsis thaliana sni1 Col-0 x Ct-1 F2 populations using genotyping-by-sequencing
Genomic DNA from 241 sni1-/- Col x Ct F2 individuals was extracted by CTAB and used to generate sequencing libraries as previously described (Hennig et al, 2018 G3). Sequencing data was analysed to identify crossovers using the TIGER pipeline as previously described (Rowan et al, 2015 G3; Yelina et ...
ORGANISM(S): Arabidopsis thaliana 
2020-12-31 | E-MTAB-9413 | biostudies-arrayexpress
UnknownEscaping but not the inactive X-linked protein complex coding genes may achieve X-chromosome dosage compensation and underlie X chromosome inactivation-related diseases.
Not available
S-EPMC10336589 | biostudies-literature
UnknownScrutinizing the double superconducting gaps and strong coupling pairing in (Li(1-x)Fe(x))OHFeSe.
Not available
S-EPMC4740187 | biostudies-literature
ProteomicsTargeting microRNA-dependent control of X chromosome inactivation improves the Rett Syndrome phenotype
The X chromosome inactivation (XCI) is induced by Xist long non-coding RNA and protein-coding genes. However, the small non-coding RNA function in XCI remains unidentified. Our genome-wide, loss-of-function CRISPR/Cas9 screen in female fibroblasts examines the role of microRNA (miRNAs) in XCI. A str...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-09 | PXD064749 | Pride
Lcms Mus mus Chirp-ms 
UnknownInferring the three-dimensional structures of the X-chromosome during X-inactivation.
Not available
S-EPMC7772933 | biostudies-literature
UnknownThe Zhu-Lu formula: a machine learning-based intraocular lens power calculation formula for highly myopic eyes.
Not available
S-EPMC10233923 | biostudies-literature
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