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ProteomicsMetal ion-decorated ZIC-cHILIC StageTip Enables Simultaneous Profiling of N-Glycoproteome and Phosphoproteome in TKI resistant NSCLC cells
Cell membrane proteins are densely decorated with surface glycosylation and intracellular phosphorylation whose interplay determines the cell-cell communication and signaling cascades. However, their concomitant characterization remains extreme challenges due to complexity of glycan structures, low ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-04 | PXD056077 | Pride
Phosphoproteome N-glycoproteome Zic-chilic 
ProteomicsSialo-glycoproteome of Human lung cancer cell by LC-MSMS
Alterations in protein glycosylation, especially the terminal sialylation, are closely correlated with physiological and pathological regulation. Due to the low ionization efficiency of sialo-glycopeptides and frequently observed dissociation of sialic acid residues during mass spectrometry analysis...
ORGANISM(S): Homo sapiens (Human) 
2022-02-25 | PXD010456 | Pride
Sialo-glycoproteome Glycoproteome Human lung cancer 
UnknownZIC-cHILIC Functionalized Magnetic Nanoparticle for Rapid and Sensitive Glycopeptide Enrichment from <1 µL Serum.
Not available
S-EPMC8470806 | biostudies-literature
UnknownMetal Ion-Enhanced ZIC-cHILIC StageTip for N-Glycoproteomic and Phosphoproteomic Profiling in EGFR-Mutated Lung Cancer Cells
Not available
S-EPMC12289526 | biostudies-literature
UnknownHILIC-MS for Untargeted Profiling of the Free Glycation Product Diversity.
Not available
S-EPMC9783660 | biostudies-literature
ProteomicsStable isotope-resolved metabolomics reveals the abnormal brain glucose catabolism in depression based on chronic unpredictable mild stress rats
The severe harm of depression to human life has attracted great attention to neurologists, but its pathogenesis is extremely complicated and has not yet been fully elaborated. Here, we provided a new strategy for revealing the specific pathways of abnormal brain glucose catabolism in depression, whi...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-06-10 | PXD025548 | Pride
Stable isotope-resolved metabolomics Brain glucose catabolism Depression Liquid chromatography-mass spectrometry Mitochondrial structure and function 
ProteomicsAn integrated strategy reveals complex glycosylation of erythropoi-etin using top-down and bottom-up mass spectrometry
The characterization of therapeutic glycoproteins is challenging due to the structural micro- and macro-heterogeneity of the protein glycosylation. This study presents an in-depth strategy for glycosylation analysis using first-generation erythropoietin (epoetin beta), including a developed top-down...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-14 | PXD024835 | Pride
Erythropoietin Bottom-up Top-down Mass spectrometry Glycosylation Python scripts 
MetabolomicsMetabolic reprogramming is an initial step in pancreatic carcinogenesis that can be targeted to inhibit acinar-to-ductal metaplasia

Metabolic reprogramming is a hallmark of cancer and is crucial for cancer progression, making it an attractive therapeutic target. Understanding the role of metabolic reprogramming in cancer initiation could help identify prevention strategies. To address this, we investigated metabolism during a...

2024-05-31 | MTBLS9772 | MetaboLights
MetabolomicsHypusination Orchestrates the Antimicrobial Response of Macrophages
Innate responses of myeloid cells defend against pathogenic bacteria via inducible effectors. Deoxyhypusine synthase (DHPS) catalyzes the transfer of the N-moiety of spermidine to the lysine-50 residue of eukaryotic translation initiation factor 5A (EIF5A) to form the amino acid hypusine. Hypusinate...
2021-04-06 | MTBLS607 | MetaboLights
MetabolomicsOrnithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis of Helicobacter pylori Infection

Colonization by H. pylori is associated with a wide range of gastric diseases, ranging from superficial gastritis to more severe pathologies, including intestinal metaplasia and adenocarcinoma. The interplay of the host response and the pathogen affect the outcome of disease. One major component ...

2022-06-15 | MTBLS3235 | MetaboLights
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