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TranscriptomicsK450 arrays leukocyte subsets
DNA methylation profiles of primary human leukocyte subsets. Complementary MeDIP-seq data for the same samples have been deposited in ArrayExpress under accession number E-ERAD-179 (https://www.ebi.ac.uk/arrayexpress/experiments/E-ERAD-179/) .
ORGANISM(S): Homo sapiens 
2013-12-09 | E-MTAB-2145 | biostudies-arrayexpress
TranscriptomicsDNA-methylation profiling of human induced pluripotent stem cell -derived intestinal epithelial organoids
The purpose of this study was to characterise iPSC-derived human intestinal epithelial organoids (iPSCo) by comparing these cultures with primary purified intestinal epithelial cells (IEC). Intestinal epithelial organoid (IEO) cultures were derived from at least three different lines of iPSCs, DNA ...
ORGANISM(S): Homo sapiens 
2018-10-23 | E-MTAB-7289 | biostudies-arrayexpress
TranscriptomicsDNA methylation in oesophageal biopsies of children diagnosed with Eosinophilic Oesophagitis (EoE) and controls
Eosinophilic oesophagitis (EoE) is a leading cause of dysphagia and food impaction in children and adults. In this pilot study, we performed genome-wide DNA methylation analyses on oesophageal biopsies obtained from children diagnosed with EoE (at diagnosis and after treatment) and matched controls....
ORGANISM(S): Homo sapiens 
2021-07-01 | E-MTAB-9824 | biostudies-arrayexpress
TranscriptomicsDNA methylation of purified intestinal epithelial cells from treatment-naive paediatric IBD patients and controls
'Illumina Infinium HumanMethylation450 BeadChip data from CD326+ sorted colonic epithelial cells of mucosal biopsies from treatment-naive paediatric IBD patients (Crohn''s Disease or Ulcerative Colitis) or age-matched controls AC= ascending colon, PSC=sigmoid colon'
ORGANISM(S): Homo sapiens 
2015-09-15 | E-MTAB-3709 | biostudies-arrayexpress
TranscriptomicsPurified intestinal epithelial cells from foetal and paediatric gut
CD326+ sorted intestinal epithelial cells from foetal (9-12 wk gestational age) small bowel and large bowel, CD326+ sorted intestinal epithelial cells from mucosal biopsies of paediatric (5-15 years of age) terminal illeum, ascending colon and sigmoid colon FPG=Foetal proximal gut, FDG=Foetal distal...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-MTAB-3703 | biostudies-arrayexpress
TranscriptomicsPurified intestinal epithelial cells from foetal and paediatric gut
CD326+ sorted intestinal epithelial cells from foetal (9-12 wk gestational age) small bowel and large bowel, CD326+ sorted intestinal epithelial cells from mucosal biopsies of paediatric (5-15 years of age) terminal illeum, ascending colon and sigmoid colon FPG=Foetal proximal gut, FDG=Foetal distal...
ORGANISM(S): Homo sapiens 
2015-09-15 | E-MTAB-3704 | biostudies-arrayexpress
TranscriptomicsMethylation profiling of human paediatric CD8+ T-cells in Crohn's Disease
CD8+ T-cell gene expression has been implicated in the pathogenesis of Inflammatory Bowel Diseases (IBD) and has been shown to correlate with disease outcome in adult patients. We aimed to explore DNA methylation in children newly diagnosed with Crohn's Disease and test for correlation with disease ...
ORGANISM(S): Homo sapiens 
2020-10-01 | E-MTAB-8925 | biostudies-arrayexpress
TranscriptomicsRNA sequencing of purified intestinal epithelial cells from paediatric biopsies including Inflammatory Bowel Disease and healthy controls
This study investigated alterations in the transcriptomic profiles of intestinal epithelial cells in Inflammatory Bowel Diseases (IBD), i.e. Crohn's Disease and Ulcerative Colitis. Biopsies were taken from treatment-naive paediatric patients at diagnostic endoscopy from terminal ileum (TI), ascendi...
ORGANISM(S): Homo sapiens 
2017-10-16 | E-MTAB-5464 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of human paediatric CD8+ T-cells in Inflammatory Bowel Diseases
Differences in CD8+ T-cell expression have previously been reported to correlate with disease outcome in adult patients diagnosed with Inflammatory Bowel Diseases (IBD). In addition, T-cell exhaustion was found to be associated with a milder disease course in adults. The purpose of this study was t...
ORGANISM(S): Homo sapiens 
2019-09-01 | E-MTAB-7923 | biostudies-arrayexpress
TranscriptomicsDNA methylation profiling of intestinal epithelial cells from paediatric biopsies including Inflammatory Bowel disease and healthy controls
We purified the intestinal epithelial cells from biopsies taken from the ileum and colon of a paediatric cohort of IBD patients and healthy controls
ORGANISM(S): Homo sapiens 
2017-10-20 | E-MTAB-5463 | biostudies-arrayexpress
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