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ProteomicsProteomics and phosphoproteomics of Staphylococcus aureus
Staphylococcus aureus colonizes 30 to 50% of healthy adults and can cause a variety of diseases, ranging from superficial to life-threatening invasive infections such as bacteraemia and endocarditis. Often, these infections are chronic and difficult-to-treat despite adequate antibiotic therapy. Pers...
ORGANISM(S): Staphylococcus aureus 
2026-10-05 | PXD025124 | Pride
Phospho-regualtion Persister Staphylococcus aureus 
ProteomicsProteomics and phosphoproteomics of Staphylococcus aureus
Staphylococcus aureus colonizes 30 to 50% of healthy adults and can cause a variety of diseases, ranging from superficial to life-threatening invasive infections such as bacteraemia and endocarditis. Often, these infections are chronic and difficult-to-treat despite adequate antibiotic therapy. Pers...
ORGANISM(S): Staphylococcus aureus 
2026-10-05 | PXD035015 | Pride
Stp Phosphoproteome Quiescence Pknb Antibiotic persistence Staphylococcus aureus 
ProteomicsNeutrophil and monocyte dysfunctional effector response towards bacterial challenge in critically ill COVID-19 patients
In this study, we aim to evaluate the relation between COVID-19 and bacterial secondary superinfections. We assessed the functional responses of neutrophils and monocytes isolated from acute and recovery COVID-19 patients upon bacterial infection using Flow-cytometry and proteomics based assays. Bot...
ORGANISM(S): Homo sapiens (Human) 
2021-12-10 | PXD029547 | Pride
Covid-19 Effector response Reactive oxygen species Streptococcus pneumoniae Bacterial superinfections Staphylococcus aureus Neutrophils Hypercytokinemia Monocytes 
ProteomicsStress adaptation within the host effects antibiotic tolerance and treatment outcome in Staphylococcus aureus infections
Staphylococcus aureus can cause severe invasive infections that require prolonged antibiotic treatment. Although S. aureus can easily acquire antibiotic resistance, even fully susceptible bacteria can persist and survive antibiotic therapy, thus complicating treatment. These so-called persisters are...
ORGANISM(S): Bacteria Staphylococcus aureus 
2021-02-12 | PXD018332 | Pride
Stress response Antibiotic persistence Staphylococcus aureus 
MetabolomicsRapid detection of Staphylococcus aureus and Streptococcus pneumoniae by real-time analysis of volatile metabolites
Early detection of pathogenic bacteria is needed for rapid diagnostics allowing adequate and timely treatment of infections. In this study, we show that Secondary Electro-Spray Ionization-High Resolution Mass Spectrometry (SESI-HRMS) can be used as a diagnostic tool for rapid detection of bacterial ...
2022-07-06 | MTBLS5085 | MetaboLights
GenomicsMolecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success
Molecular reprogramming and phenotype switching in Staphylococcus aureus lead to high antibiotic persistence and affect therapy success
PRJNA622829 | ENA
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