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MetabolomicsLipid biomarkers for algal resistance to viral infection in the ocean

Marine viruses play a key role in regulating phytoplankton populations, greatly affecting the biogeochemical cycling of major nutrients in the ocean. Resistance to viral infection has been reported for various phytoplankton species under laboratory conditions. Nevertheless, the occurrence of resi...

2023-06-12 | MTBLS3323 | MetaboLights
ProteomicsSolar exposed skin induces sex-dependent food-seeking behavior
Considering the distinct physiologies of men and women, it stands to reason that they would react differently to solar exposure, but such a study was never conducted before. Here we show that solar exposure induces food-seeking behavior, food intake and weight gain in males, but not in females, by ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033203 | Pride
Food-seeking Solar exposure Serum 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 2
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035648 | Pride
Metabolism Cancer Exercise 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 1
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035630 | Pride
Metabolism Cancer Exercise 
MetabolomicsIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids (GC- and LC-MS assays)

Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited...

2018-11-29 | MTBLS767 | MetaboLights
ProteomicsSecond-Hand Melanoma Melanosomes Regulate Diversity Among Tumor-Associated Macrophages
Extracellular vesicles (EVs) are a key form of cell-to-cell communication. Here we reveal a new mode of communication involving the large EVs, melanosomes. Unlike small EVsexosomes, which are dissolved in the receiver cell, melanosomes stay intact within them, gain a unique protein signature, and ca...
ORGANISM(S): Homo sapiens (Human) 
2023-12-31 | PXD046421 | Pride
Melanosomes Macrophages Small ev 
ProteomicsSkin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior
Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual behavioral and hormonal features enhanced by UVB are mediated by the skin. In mice, UV exposure increases...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025973 | Pride
Proteomics Uvb light Sexual behavior 
MetabolomicsIn plaque-mass spectrometry imaging of a bloom-forming alga during viral infection reveals a metabolic shift towards odd-chain fatty acid lipids (Imaging MS assays)

Tapping into the metabolic cross-talk between a host and its virus can reveal unique strategies employed during infection. Viral infection is a dynamic process that generates an evolving metabolic landscape. Gaining a continuous view into the infection process is highly challenging and is limited...

2018-11-29 | MTBLS769 | MetaboLights
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