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ProteomicsDependence of Synaptic Protein Degradation on Proteasomal Function -Part2
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematically studied how inhibition of the ubiquitin-protea...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD004726 | Pride
Proteomics Synaptic protein Degradation 
ProteomicsDependence of Synaptic Protein Degradation on Proteasomal Function -Part3
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematically studied how inhibition of the ubiquitin-protea...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD004711 | Pride
Proteomics Synaptic protein Degradation 
ProteomicsDependence of Synaptic Protein Degradation on Proteasomal Function
Synaptic function crucially depends on uninterrupted synthesis and degradation of synaptic proteins. While much has been learned on synaptic protein synthesis, little is known on the routes by which synaptic proteins are degraded. Here we systematically studied how inhibition of the ubiquitin-protea...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-10-26 | PXD004813 | Pride
Proteomics Synaptic protein Degradation 
ProteomicsSite-Specific Ubiquitination of Pathogenic Huntingtin Attenuates its Deleterious Effects
Huntington’s disease (HD) is a progressive incurable neurodegenerative disorder characterized by motor and neuropsychiatric symptoms. It is caused by expansion of a CAG triplet in the N-terminal domain of exon 1 in the huntingtin (HTT) gene that codes for an expanded polyglutamine (polyQ) stretch in...
ORGANISM(S): Rattus rattus (Black rat) 
2020-06-30 | PXD019553 | Pride
Huntingtin ubiquitination 
ProteomicsSite-Specific Ubiquitination of Pathogenic Huntingtin Attenuates its Deleterious Effects- PART2
Huntington’s disease (HD) is a progressive incurable neurodegenerative disorder characterized by motor and neuropsychiatric symptoms. It is caused by expansion of a CAG triplet in the N-terminal domain of exon 1 in the huntingtin (HTT) gene that codes for an expanded polyglutamine (polyQ) stretch in...
ORGANISM(S): Homo sapiens (Human) 
2020-06-30 | PXD019552 | Pride
Ubiquitination huntingtin 
ProteomicsSchistosomes- exosomal miRNAs: modulators of T helper (CD+) cell differentiation
Schistosomiasis (Bilharziasis) is caused by the helminth Schistosoma. The acute stage of the infection extends from the penetration of the parasite through the host skin until it reaches its final location as adult female and male in copula, at the blood vessels around the gut or bladder. The female...
ORGANISM(S): Bos taurus (Bovine) 
2019-12-10 | PXD012525 | Pride
Mirna T helper Schistosomes 
ProteomicsSenescent cancer-associated fibroblasts in pancreatic adenocarcinoma impair CD8+ T cell activation and limit responsiveness to immunotherapy in mice
Senescent cells within tumors and their stroma exert complex pro- and anti-tumorigenic functions, yet the potential for targeting such senescent cells for improved therapy remains largely unknown. Here, we uncover the presence of a senescent subset of cancer-associated fibroblasts (CAFs) within panc...
ORGANISM(S): Homo sapiens (Human) 
2024-06-24 | PXD053144 | Pride
: senescence Venetoclax Pancreatic ductal adenocarcinoma (pdac) Senolytics Cancer associated fibroblasts (cafs) Immunotherapy Abt-199 T cells 
ProteomicsSecretome analysis of Arabidopsis thaliana and Trichoderma atroviride reveals a diverse and dynamic repertoire of extracellular enzymes that may play a role during symbiotic interaction
The establishment of plant-mutualistic fungi interaction requires a bidirectional molecular crosstalk. The study of their secretomes help to understand a beneficial relationship. Here, a gel-free shotgun proteomic approach was used to identify secreted proteins from semi hydroponic culture systems w...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) Trichoderma atroviride 
2021-09-09 | PXD023283 | Pride
Symbiotic interaction Secretome Trichoderma 
ProteomicsSoluble CD72 (sCD72)I, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity
Background: CD72 is a highly required regulatory molecule in B cells. Its sufficient expression is crucial for maintaining self-tolerance. In contrast, soluble CD72 (sCD72) is reported to be increased in the serum of autoimmune diseases such as systemic lupus erythematosus and primary Sjogren's syn...
ORGANISM(S): Homo sapiens (Human) 
2024-07-01 | PXD053518 | Pride
Cd72 Autoimmune diseases 
ProteomicsUBQLN4, a regulator of protein dynamics at sites of DNA damage, is lost in a new genome instability syndrome and elevated in aggressive tumors
The ubiquitin-proteasome system (UPS) plays a crucial role in cellular homeostasis, but the mechanistic aspects of its involvement in the DNA damage response (DDR) remain largely elusive. Here, we identify a homozygous truncation mutation in the UBQLN4 gene in families with highly pleiotropic autoso...
ORGANISM(S): Homo sapiens (Human) 
2020-06-02 | PXD008299 | Pride
Dna damage Lc-ms Proteomics Ubqln4 
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