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ProteomicsSurface proteomics reveals CD72 as a target for in vitro-evolved nanobody-based CAR-T cells in refractory B-cell malignancies
Alternate strategies are needed for B-cell malignancy patients relapsing after CD19-targeted immunotherapy. Here, integrated cell surface proteomics and epigenetic analysis initially revealed CD72 as an optimal target for poor-prognosis MLL-rearranged B-ALL, which we further found to be expressed wi...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD016800 | Pride
B-all Cell surface Cd72 
GenomicsSingle-cell RNA-seq analysis of PDX (Patient-Derived Xenograft) tumors isolated from mouse spleens, treated with Empty CAR, anti-CD72 H24 nanoCAR or anti-CD72 NbD4.13 nanoCAR.
Single-cell RNA-seq analysis of PDX (Patient-Derived Xenograft) tumors isolated from mouse spleens, treated with Empty CAR, anti-CD72 H24 nanoCAR or anti-CD72 NbD4.13 nanoCAR.
PRJNA1229542 | ENA
ProteomicsSoluble CD72 (sCD72)I, is a T-cell activator probably via binding to CD6 in homeostasis and autoimmunity
Background: CD72 is a highly required regulatory molecule in B cells. Its sufficient expression is crucial for maintaining self-tolerance. In contrast, soluble CD72 (sCD72) is reported to be increased in the serum of autoimmune diseases such as systemic lupus erythematosus and primary Sjogren's syn...
ORGANISM(S): Homo sapiens (Human) 
2024-07-01 | PXD053518 | Pride
Cd72 Autoimmune diseases 
UnknownCD72 regulates the growth of KIT-mutated leukemia cell line Kasumi-1.
Not available
S-EPMC3980566 | biostudies-literature
UnknownModulation of peripheral B cell tolerance by CD72 in a murine model.
Not available
S-EPMC2790383 | biostudies-literature
TranscriptomicsSingle-cell RNA-seq analysis of PDX (Patient-Derived Xenograft) tumors isolated from mouse spleens, treated with Empty CAR, anti-CD72 H24 nanoCAR or anti-CD72 NbD4.13 nanoCAR.
Single-cell RNA-seq analysis was performed on human mantle cell lymphoma PDX (Patient-Derived Xenograft) tumors isolated from mouse spleens to examine gene expression changes after treatment of Empty CAR, humanized anti-CD72 nanobody-based CAR-T (“H24 nanoCAR”) or NbD4.13-based anti-CD72 nanoCAR-T.
ORGANISM(S): Mus musculus 
2026-02-23 | GSE290685 | GEO
UnknownFramework humanization optimizes potency of anti-CD72 nanobody CAR-T cells for B-cell malignancies.
Not available
S-EPMC10680002 | biostudies-literature
UnknownAffinity-matured CD72-targeting nanobody CAR T cells enhance elimination of antigen-low B-cell malignancies.
Not available
S-EPMC12766774 | biostudies-literature
UnknownAffinity-matured CD72-targeting Nanobody CAR T-cells Enhance Elimination of Antigen-Low B-cell Malignancies.
Not available
S-EPMC12132434 | biostudies-literature
TranscriptomicsDeletion 9p drives B-cell leukemia by the concomitant loss of Pax5 and Cd72
We used microarrays to analyze gene expression changes in preleukemic cells from Cd72+/-;Pax5+/-, Pax5+/- and WT mice. The oncogenic role of 9p deletion in B-ALL has remained elusive since its discovery more than 40 years ago. We combined genomic analysis and functional models to show that the co-de...
ORGANISM(S): Mus musculus 
2026-02-09 | GSE302482 | GEO
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