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Study of Trypanosoma ZMYND12’s ortholog (TbTAX-1) confirmed an axonemal localization of the protein and knockdown of TbTAX-1 using RNAi induced dramatic flagellar motility defects as observed in human. Co-immunoprecipitation assays and ultra-structure expansion microscopy in Trypanosoma brucei then ...
ORGANISM(S): Trypanosoma brucei 
2023-11-01 | PXD039470 | Pride
Meckel Syndrome, Nephronophthisis, Joubert Syndrome, and Bardet-Biedl Syndrome have mutations in proteins that localize to the ciliary transition zone (TZ). The phenotypically distinct syndromes suggest these TZ proteins have differing functions. However, mutations in a single TZ gene can result in ...
ORGANISM(S): Danio rerio 
2022-11-30 | GSE217001 | GEO
Variable phenotypes and penetrance between and within different zebrafish transition zone mutants
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