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TranscriptomicsTranscription profiling of four mouse bone marrow hematopoietic stem cells (HSC) early B lineage stages(MLP, CLP, Fr.A, Fr.B) to identify coordinately regulated gene as cells progress down the B cell development pathway
Differentiation from hematopoietic stem cells (HSC) to early B-lineage cells proceeds through a series of intermediate stages, during which cells are thought to become progressively more restricted in their developmental potential. RNAs were prepared from four early B lineage stages(MLP, CLP, Fr.A, ...
ORGANISM(S): Mus musculus 
2006-12-16 | E-MEXP-559 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing from human salivary glands from Sjogren's disease patients recruited in the TRACTISS randomized clinical trial
Sjogren's disease patients received Rituximab (anti-CD20 depleting monoclonal antibody) or placebo treatment. This study aims to identify the transcriptomic features of salivary gland biopsies, the target tissue of the autoimmune response in Sjögren’s disease. It examines transcriptomic changes in s...
ORGANISM(S): Homo sapiens 
2025-06-30 | E-MTAB-15225 | biostudies-arrayexpress
TranscriptomicsU-87 MG Temozolomide-Induced Senescence RNA-seq Dataset
We analyzed the U-87 MG cell line, which was treated with temozolomide for 5 days to induce a senescent state. The study aimed to investigate molecular and phenotypic alterations associated with senescence in the context of a malignant phenotype. Senescence was confirmed through β-galactosidase stai...
ORGANISM(S): Homo sapiens 
2025-05-14 | E-MTAB-15106 | biostudies-arrayexpress
TranscriptomicsSaccharomyces cerevisiae cells: control vs positive supercoiling accumulation after 0, 30 and 120 min
Positive DNA helical stress accumulates in vivo by the unbalanced relaxation of positive and negative DNA supercoils in Δtop1, top2ts, pGPD:TopA yeast cells. The resulting overwinding of DNA greatly diminishes overall RNA synthesis. Here we show that whereas most genes reduce their transcript level...
ORGANISM(S): Saccharomyces cerevisiae 
2010-05-19 | E-GEOD-18240 | biostudies-arrayexpress
TranscriptomicsBASE-A space experiment with Rhodospirillum rubrum S1H
R. rubrum S1H inoculated on solid minimal media was sent to the ISS in September 2006 (BASE-A experiment). After 10 days flight, R. rubrum cultures returned back to Earth. These cultures were then subjected to both transcriptomic and proteomic analysis and compared with the corresponding ground cont...
ORGANISM(S): Rhodospirillum rubrum 
2010-05-16 | E-GEOD-14241 | biostudies-arrayexpress
TranscriptomicsFolsomia candida exposed to soil containing different phenanthrene concentrations
Polycyclic aromatic hydrocarbons are common pollutants in soil, have negative effects on soil ecosystems, and are potentially carcinogenic. The Springtail (Collembola) Folsomia candida is often used as an indicator species for soil toxicity. Here we report a toxicogenomic study that translates the e...
ORGANISM(S): Folsomia candida 
2010-05-18 | E-GEOD-14207 | biostudies-arrayexpress
TranscriptomicsscRNA-seq of GFP+ cells isolated from developing 24 hpf mnx1:GFP zebrafish embryos
In this study, we performed single-cell RNA-sequencing (scRNA-seq) on 24 hours post-fertilization (hpf) mnx1:GFP zebrafish embryos to characterize the transcriptional diversity of developing spinal motor neurons. Our goal was to identify molecularly distinct subtypes within the motor neuron populati...
ORGANISM(S): Danio rerio 
2025-11-11 | E-MTAB-15160 | biostudies-arrayexpress
TranscriptomicsAn Alternative Splicing Event Amplifies Evolutionary Differences Between Vertebrates
Alternative splicing (AS) generates extensive transcriptomic and proteomic complexity. However, the functions of species- and lineage-specific splice variants are largely unknown. Here, we show that mammalian-specific skipping of exon 9 of PTBP1 alters its splicing regulatory activities and affects ...
ORGANISM(S): Homo sapiens 
2015-09-01 | E-GEOD-69656 | biostudies-arrayexpress
TranscriptomicsIdentification of mesendoderm precursor- and neurectoderm precursor-enriched genes in Zebrafish embryos
We have developed a method for rapidly identifying early, regionally-expressed molecules: FACS-Assisted Microdissection of Photolabeled cells (FAM-P). For our first FAM-P project, we injected embryos with purified Kaede protein, a stony coral protein that fluoresces at 514 nm (green) prior to- and 5...
ORGANISM(S): Danio rerio 
2010-05-26 | E-GEOD-8654 | biostudies-arrayexpress
TranscriptomicsExpression data for UPEC and GBS cystitis in female C57BL/6 mice
Data defines for the first time a whole bladder transcriptome of UPEC cystitis in female C57BL/6 mice using genome-wide expression profiling and temporal analysis to map early host response pathways stemming from UPEC colonization We used microarrays to detail the global programme of gene expression...
ORGANISM(S): Mus musculus 
2012-06-30 | E-GEOD-27575 | biostudies-arrayexpress
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