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Double membrane vesicles (DMVs) are used as replication organelles by pathogenic RNA viruses such as hepatitis C virus (HCV) and severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Viral DMVs are morphologically analogous to DMVs formed during autophagy, and although the proteins required...
ORGANISM(S): Homo sapiens (Human) 
2022-01-24 | PXD029692 | Pride
The recovery of other pathogens in COVID-19 patients has been reported. The presence of either co-infection or superinfection with bacterial pathogens was associated with poor outcomes, including increased mortality. The recognition of possibility of SARS-CoV-2 co-infection is important as it enable...
ORGANISM(S): Streptococcus pneumoniae Staphylococcus aureus 
2022-04-04 | PXD029967 | Pride
The Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), first identified in November 2021 in South Africa, has initiated the 5th wave of global pandemics. Here, we systemically examined immunological and metabolic characteristics of Omicron variants infection. We found ...
ORGANISM(S): Cercopithecus aethiops (Green monkey) (Grivet) 
2023-03-11 | PXD037955 | Pride
The COVID-19 pandemic highlighted the urgent need to develop effective and broad-spectrum antiviral therapies against coronaviruses. One strategy to address this concern is combination therapy using repurposed drugs against zoonotic viruses with pandemic potential. We previously demonstrated that th...
ORGANISM(S): Mus musculus (Mouse) Betacoronavirus 
2026-09-07 | PXD073706 | Pride
00502 protein derived from Paraprevotella clara, as well as mixture of 00502 protein and human PRSS2 were analyzed by Native-PAGE. The observed bands were cut out and digested in-gel. The digested peptides were analyzed by DDA-MS using Q Exactive HF-X .
ORGANISM(S): Paraprevotella Clara 
Recent developments have broadened our perception of SARS-CoV-2, indicating its capability to affect the body systemically beyond its initial recognition as a mere respiratory pathogen. However, the pathways of its widespread are not well-understood. Employing a dual-modality approach, we integrated...
ORGANISM(S): Severe acute respiratory syndrome coronavirus 2 Mus musculus (Mouse) 
2024-12-11 | PXD054355 | Pride
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