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MetabolomicsF1Fo-ATP synthase subunit determines lethal pathogenic fungi infection
Fungal infections, especially candidiasis and aspergillosis, claim an unacceptably high fatality rate. The energy ATP that is necessary for fungal cell growth and function is synthesized mainly through oxidative phosphorylation, with the key enzyme being F1Fo-ATP synthase. But it remains unknown how...
2021-10-08 | MTBLS3332 | MetaboLights
MetabolomicsSerine Metabolism Tunes Immune Responses To Promote Oreochromis niloticus Survival upon Edwardsiella tarda Infection
Overactive immune response is a critical factor triggering host death upon bacterial infection. However, the mechanism behind the regulation of excessive immune responses is still largely unknown, and the corresponding control and preventive measures are also to be explored. In this study, we find t...
2021-08-18 | MTBLS2974 | MetaboLights
MetabolomicsA profile of the joint Toxoplasma-host infection metabolome finds broad changes to metabolism and discovers a novel parasite metabolic capability
The obligate intracellular parasite Toxoplasma gondii is auxotrophic for several key metabolites and must scavenge these, and carbon sources like glucose. from the host. While the importance of metabolism to Toxoplasma infection it obvious, it is unclear how Toxoplasma infection actually changes met...
2019-05-10 | MTBLS899 | MetaboLights
TranscriptomicsTranscription profiling of mouse spleen from animals exposed to Ebola virus reveals reduced levels of protein tyrosine phosphatase CD45 protect mice from the lethal effects of Ebola virus infection
To gain insight into the changes in gene expression pattern upon Ebola infection, CD45+/+ (100% protein level) and CD45+/- (62% protein level) mice were challenged with mouse adapted Ebola virus. At time-points day 0, 1, 3, 5, 7, 9, 11 and 13, spleen tissue was harvested and splenocytes isolated. To...
ORGANISM(S): Mus musculus 
2009-09-05 | E-GEOD-17509 | biostudies-arrayexpress
TranscriptomicsMicroRNA miR-223 constrains lethal inflammation during Mycobacterium tuberculosis infection
The molecular mechanisms that control innate cell recruitment during chronic infection and inflammation, such as tuberculosis (TB), are incompletely understood. During TB, myeloid cells infiltrate the lung and sustain local inflammation. We identified microRNA (miR)-223 as one of the most abundant n...
ORGANISM(S): Homo sapiens 
2014-04-21 | E-GEOD-39163 | biostudies-arrayexpress
TranscriptomicsIdentification of biological processes that distinguish lethal from non-lethal influenza infection
Identification of biological processes that distinguish lethal from non-lethal influenza infection and further use of these signatures in a top-down systems analysis investigating the relative pathogenic contributions of direct viral damage to lung epithelium vs. dysregulated immunity to during leth...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-42638 | biostudies-arrayexpress
TranscriptomicsTranscriptomic comparison of 5 cell types during lethal and non-lethal influenza infection
Transcriptomic comparison of 5 cell types during lethal and non-lethal influenza infection and further use of these signatures in a top-down systems analysis investigating the relative pathogenic contributions of direct viral damage to lung epithelium vs. dysregulated immunity during lethal influenz...
ORGANISM(S): Mus musculus 
2013-07-03 | E-GEOD-42639 | biostudies-arrayexpress
ProteomicsF1Fo-ATP synthase subunit determines lethal infection in pathogenic fungi
Fungal infections, especially for candidiasis and aspergillosis, claim an unacceptably high fatality. However, the determining mechanism that promote fungal lethal infections are still elusive. The energy ATP necessary for fungal cell growth and function is synthesized mainly through oxidative phosp...
ORGANISM(S): Candida albicans (Yeast) 
2021-09-16 | PXD024729 | Pride
subunit lethal infection pathogenic fungi 
TranscriptomicsComparative transcriptomic analysis of BA- or BL- associated murine colonic epithelium after O157 infection
A huge number of microorganisms are colonized in human gut and the balance of their composition is closely related to human health. Recently, many probiotics such as bifidobacteria or lactobacilli have been introduced in our life as effective agents. However, we have not well understood their benefi...
ORGANISM(S): Mus musculus 
2011-01-27 | E-GEOD-12998 | biostudies-arrayexpress
GenomicsMicroRNA miR-223 constrains lethal inflammation during Mycobacterium tuberculosis infection
MicroRNA miR-223 constrains lethal inflammation during Mycobacterium tuberculosis infection
PRJNA170123 | ENA
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