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TranscriptomicsA calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells
The response of osteoprogenitors to calcium (Ca2+) is of primary interest for both normal bone homeostasis and the clinical field of bone regeneration. The latter makes use of calcium phosphate-based bone void fillers to heal bone defects, but it is currently not known how Ca2+ released from these c...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7222 | biostudies-arrayexpress
TranscriptomicsA small molecule approach to engineering vascularized tissue
The repertoire of growth factors determines the biological engagement of human mesenchymal stromal cells (hMSCs) in processes such as immunomodulation and tissue repair. Hypoxia is a strong modulator of the secretome and well known stimuli to increase the secretion of pro-angiogenic molecules. In th...
ORGANISM(S): Homo sapiens 
2018-10-04 | E-MTAB-7209 | biostudies-arrayexpress
TranscriptomicsBioinformatics-based selection of a model cell type for in vitro biomaterial testing
Biomaterial properties can be tailored for specific applications via systematic and high-throughput screening of biomaterial–cell interactions. However, progress in material development is often hampered by the lack of adequate in vitro testing methods, frequently due to incomplete understanding of ...
ORGANISM(S): Homo sapiens 
2018-08-12 | E-MTAB-7057 | biostudies-arrayexpress
TranscriptomicsPro-osteogenic trophic effects by PKA activation in human mesenchymal stromal cells
Human mesenchymal stromal cells (hMSCs) are able to differentiate into a wide variety of cell types, which makes them an interesting source for tissue engineering applications. On the other hand, these cells also secrete a broad panel of growth factors and cytokines that can exert trophic effects on...
ORGANISM(S): Homo sapiens 
2018-10-06 | E-MTAB-7224 | biostudies-arrayexpress
TranscriptomicsDiverse effects of cyclic AMP variants on osteogenic and adipogenic differentiation of human mesenchymal stromal cells
Osteogenic differentiation of human mesenchymal stromal cells (hMSCs) may potentially be used in cell-based bone tissue-engineering applications to enhance the bone-forming potential of these cells. Osteogenic differentiation and adipogenic differentiation are thought to be mutually exclusive, and a...
ORGANISM(S): Homo sapiens 
2018-08-05 | E-MTAB-7038 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of MG-63 cells grown on different biomaterials used in bone grafts
During the past decades, there have been major advances in the field of biomaterials, thereby generating a vast variety of materials for a broad range of tissue engineering and regeneration applications. Although gene expression profiling has been used occasionally in biomaterial research, its usefu...
ORGANISM(S): Homo sapiens 
2018-10-05 | E-MTAB-7219 | biostudies-arrayexpress
TranscriptomicsPredicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1
Mesenchymal stromal cells (hMSCs) are advancing into the clinic but the therapeutic efficacy of hMSCs faces the problem of donor variability. In bone tissue engineering, no reliable markers have been identified which are able to predict the bone-forming capacity of hMSCs prior to implantation. To th...
ORGANISM(S): Homo sapiens 
2018-10-04 | E-MTAB-7210 | biostudies-arrayexpress
TranscriptomicsHigh content imaging in the screening of biomaterial-induced MSC behavior
Upon contact with a biomaterial, cells and surrounding tissues respond in a manner dictated by the physicochemical and mechanical properties of the material. Traditionally, cellular responses are monitored using invasive analytical methods that report the expression of genes or proteins. These analy...
ORGANISM(S): Homo sapiens 
2018-11-10 | E-MTAB-7352 | biostudies-arrayexpress
UnknownBrain transcriptomics highlight abundant gene expression and splicing alterations in non-neuronal cells in aFTLD-U
Not available
S-EPMC12336083 | biostudies-literature
TranscriptomicsDistinct brain transcriptome profiles in c9orf72-associated and sporadic ALS
Increasing evidence suggests that defective RNA processing contributes to the development of amyotrophic lateral sclerosis (ALS). This may be especially true for ALS caused by a repeat expansion in C9orf72 (c9ALS), in which the accumulation of RNA foci and dipeptide-repeat proteins are expected to m...
ORGANISM(S): Homo sapiens 
2015-07-19 | E-GEOD-67196 | biostudies-arrayexpress
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