Bioinformatics-based selection of a model cell type for in vitro biomaterial testing

ABSTRACT: Biomaterial properties can be tailored for specific applications via systematic and high-throughput screening of biomaterial–cell interactions. However, progress in material development is often hampered by the lack of adequate in vitro testing methods, frequently due to incomplete understanding of involved in vivo mechanisms. In line with drug discovery in pharmacology, a crucial step in assay development for biomaterial screening is the identification of a target to direct the screen against. Herein, the cell type to be used for screening is of essential importance and has to be carefully chosen. So far, few attention has been put on selecting a cell type specifically suitable for in vitro testing of materials for predefined applications. In this manuscript, we describe an approach to de

ORGANISM(S): Homo sapiens

SUBMITTER: Jan de Boer 

PROVIDER: E-MTAB-7057 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress