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TranscriptomicsDNA copy number changes in colorectal flat adenomas
Background & aim: Flat adenomas form a specific phenotype of colorectal adenomas that has been associated with more severe molecular changes and consequently a more aggressive clinical behavior compared to their polypoid counterparts. In the present study we set out to compare one of the molecular c...
ORGANISM(S): Homo sapiens 
2012-10-04 | E-GEOD-30479 | biostudies-arrayexpress
TranscriptomicsLosses of chromosome 5q and 14q mark a subset of gastric cancers with good clinical outcome
Purpose: To improve clinical outcome of gastric cancer patients, most emphasis is on improving therapeutic regimens, including more extensive surgery as well as (neo)adjuvant chemotherapy. The present study set out to identify, based on DNA copy number profiling, subgroups of patients with different...
ORGANISM(S): Homo sapiens 
2012-05-09 | E-GEOD-26389 | biostudies-arrayexpress
TranscriptomicsGenomic landscape of metastatic colorectal cancer
Response to drug therapy in individual colorectal cancer (CRC) patients is associated with tumor biology. Here we describe the genomic landscape of tumor samples of a homogeneous well-annotated series of patients with metastatic CRC of two phase III clinical trials, CAIRO and CAIRO2. DNA copy number...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-36864 | biostudies-arrayexpress
TranscriptomicsSmall bowel adenocarcinoma copy number profiles are more closely related to colorectal than to gastric cancers
Purpose: Small bowel adenocarcinoma (SBA) is a rare cancer and consequently the number of clinical trials has been very limited due to the small numbers of patients. Chemotherapy regimens are currently rather arbitrarily chosen between either a colorectal (CRC) or a gastric cancer (GC) regimen. Chr...
ORGANISM(S): Homo sapiens 
2011-06-13 | E-GEOD-23418 | biostudies-arrayexpress
TranscriptomicsRecurrent breakpoint genes in colorectal cancer
In this study our aim was to document recurrent DNA copy number aberration associated breakpoints in primary tumors of colorectal cancer patients that ultimately received systemic treatment in the context of metastatic disease. Such data can be used to catalogue copy number aberration associated bre...
ORGANISM(S): Homo sapiens 
2014-11-14 | E-GEOD-63216 | biostudies-arrayexpress
TranscriptomicsGastric cancers of Western European and African patients
Gastric cancer is the second most common cause of cancer death worldwide, but incidence and mortality rates show large variations across different countries. Variation in risk factors between different populations, including environmental and host factors influencing gastric cancer risk, have been r...
ORGANISM(S): Homo sapiens 
2011-06-27 | E-GEOD-22789 | biostudies-arrayexpress
TranscriptomicsDeletion of chromosome 4q predicts outcome in Stage II colon cancer
Background: Around 30% of all stage II colon cancer patients will relapse and die of their disease. At present no objective parameters for identification of high-risk stage II colon cancer patients, who will benefit from adjuvant chemotherapy, are established. With traditional histopathological feat...
ORGANISM(S): Homo sapiens 
2010-07-13 | E-GEOD-17181 | biostudies-arrayexpress
Genomicsena-DATASET-JHU-SOM-01-09-2017-17:11:13:045-143 - samples
The dataset for Direct Detection of Early-Stage Cancers using Circulating Tumor DNA includes 602 bam files from next-generation sequencing on the Illumina HiSeq2500 or MiSeq. The samples analyzed include cancer cell lines as well as plasma and tissue specimens from healthy individuals and patients ...
EGAD00001003601 | EGA
GenomicsDirect Detection of Early-stage Cancers Using Circulating Tumor DNA
Early detection and intervention are likely to be the most effective means for reducing morbidity and mortality of human cancer. However, development of methods for noninvasive detection of early-stage tumors has remained a challenge. We have developed an approach called targeted error correction se...
EGAS00001002577 | EGA
GenomicsDAC for Direct Detection of Early-stage Cancers Using Circulating Tumor DNA
Data Access Committee EGAC00001000701
EGAC00001000701 | EGA
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