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ProteomicsFc Gamma Receptor (FcγR) Expression and Signaling in the Developing Rat Brain
Maternal antibodies specific for antigens in the developing brain are implicated as risk factors for neurodevelopmental disorders, but how these antibodies interfere with neurodevelopment remain speculative. It has been postulated that immunoglobulin G-immune complexes (IgG-IC) activate Fc gamma rec...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-01-11 | PXD006904 | Pride
Neuron culture Brain Fc gamma receptors 
ProteomicsSurfaceome dynamics and surface trafficking during neuronal development and synaptic plasticity
Surface proteins are of fundamental importance for formation of synaptic connections and activity-dependent plasticity. Here, we used a spatiotemporally resolved cell-surface proteotype analysis to characterize the neuronal surface-exposed proteome, or surfaceome, during neuronal development and syn...
ORGANISM(S): Rattus norvegicus (Rat) 
2020-10-05 | PXD014790 | Pride
Synapse Surface Neuroproteomics Spatial Surfaceome 
ProteomicsEnzymatic dissociation induces transcriptional and proteotype bias in brain cell populations
Different cell isolation techniques exist for transcriptomic and proteotype profiling of brain cells. Here we show that standard enzymatic digestion of brain tissue at 37°C induces profound alterations in the transcriptome and proteotype of specific brain cells, as compared to cold mechanical dissoc...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD015592 | Pride
Brain cell types enzymatic digestion bias isolation 
ProteomicsTissue specific protein-protein associations prioritize candidate disease associated genes
Proteins that interact together participate in the same cellular process and influence the same organismal traits. Despite the progress in mapping protein interactions we lack knowledge of how these change across tissues. Due to coordinated (post)transcriptional control, protein complex members have...
ORGANISM(S): Rattus norvegicus (Rat) 
2024-05-17 | PXD049084 | Pride
Synapse synaptosome sec 
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