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TranscriptomicsTranscription profiling of rat cardiac myocytes and fibroblasts subjected to 24 hours of mechanical stress, or treated with a single dose of ionizing or ultraviolet radiation and allowed to recover for 24 hours
Rationale: During excessive pressure or overload, cardiac cells are subjected to increased mechanical stress. We investigate how the stress response of cardiac cells to mechanical stress can be compared to genotoxic stresses induced by DNA damaging agents. Methods: Cultures enriched for cardiomyocyt...
ORGANISM(S): Rattus norvegicus 
2007-09-18 | E-GEOD-2032 | biostudies-arrayexpress
TranscriptomicsIn vitro antiplasmodial activity of Dicoma anomala subsp. gerrardii (Asteraceae): identification of its main active constituent and gene expression profiling.
To determine the transcriptional effects of a novel plant-based compound, dehydrobrachylaenolide, on P. falciparum, parasite cultures were treated with the compound over time. Samples were taken for analysis 2, 6, and 12 hours post-invasion of human red blood cells. Control cultures were treated sim...
ORGANISM(S): Plasmodium falciparum 3D7 
2011-11-01 | E-GEOD-29874 | biostudies-arrayexpress
OtherTAF10 interacts with GATA1 transcription factor and controls mouse erythropoiesis.
Data from ProteomeXchange, PXD ID: PXD000729. Experiment: hs, file: F049331.dat-pride.pride.mgf. Published as part of Mol Cell Biol. 2015 Apr 13 . From the Abstract: {{i}} The ordered assembly of a functional pre-initiation complex (PIC), composed of general transcription factors (GTFs), is a prere...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM32320015002 | GPMDB
Resource Reanalysis 
TranscriptomicsDeep sequencing of MYC DNA-binding sites in Burkitt's lymphoma
Background: MYC is a transcription factor encoded by the c-MYC gene (thereafter termed MYC). MYC is key transcription factor involved in many central cellular processes including ribosomal biogenesis. MYC is overexpressed in the majority of human tumours including aggressive B-cell lymphoma especial...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30726 | biostudies-arrayexpress
TranscriptomicsaCGH analysis of Palb2GT/+;p53-/- and Palb2+/+;p53-/- lymphomas
Palb2 interacts with BRCA1 and BRCA2 in supercomplexes involved in DNA repair via homologous recombination. Heterozygous germline mutations in PALB2 confer a moderate risk of breast cancer while biallelic PALB2 mutations are linked to a severe form of Fanconi anaemia characterized by early childhood...
ORGANISM(S): Mus musculus 
2011-01-21 | E-GEOD-26723 | biostudies-arrayexpress
TranscriptomicsDifferential expression of innate immune and metabolic genes in LPS-challenged chickens
Salmonella causes inflammation in infected hosts. Inflammation is a well-characterized defensive mechanism of innate immunity. The recognition and engagement of lipopolysaccharide (LPS) endotoxins in the outer membranes of Salmonella to Toll-like receptor 4 of immune cells (macrophages and dendritic...
ORGANISM(S): Gallus gallus 
2011-04-30 | E-GEOD-28959 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of tammar primary mammary cells challenged with E. coli-derived lipoteichoic acid or lipopolysaccharide
primary mammary cells of the tammar were cultured with 5ug/mL E. coli derived lipoteichoic acid or lipopolysaccharide for four hours. Two control groups where tammar primary mammary cells were cultured for zero and four hours without this stimulant were also used.
ORGANISM(S): Macropus eugenii 
2008-01-01 | E-TABM-350 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of by array of Streptococcus pneumoniae D39 to investigate the effect of manganese limitation
Data is also available from BuG@Sbase
ORGANISM(S): Streptococcus pneumoniae 
2010-07-22 | E-BUGS-89 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse midbrain biopsies of Nurr1 knockouts (3 pools) against 1 pool of controls
mouse midbrain biopsies of Nurr1 knockouts (3 pools) against 1 pool of controls
ORGANISM(S): Mus musculus 
2009-06-10 | E-TABM-711 | biostudies-arrayexpress
TranscriptomicsProstate CancerM-bM-^@M-^SAssociated Gene Expression Alterations Determined from Needle Biopsies
To accurately identify gene expression alterations that differentiate neoplastic from normal prostate epithelium using an approach that avoids contamination by unwanted cellular components and is not compromised by acute gene expression changes associated with tumor devascularization and resulting i...
ORGANISM(S): Homo sapiens 
2012-08-24 | E-GEOD-40373 | biostudies-arrayexpress
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