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Tanos2008 - Blood coagulation and Snake Venom


ABSTRACT: Mathematical model of the blood coagulation cascade including interaction of snake venom and antivenom.

SUBMITTER: Matthew Roberts  

PROVIDER: MODEL1806150001 | BioModels | 2018-06-15

REPOSITORIES: BioModels

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Publications

A model for venom-induced consumptive coagulopathy in snake bite.

Tanos P P PP   Isbister G K GK   Lalloo D G DG   Kirkpatrick C M J CM   Duffull S B SB  

Toxicon : official journal of the International Society on Toxinology 20080912 7


Many snake venoms contain procoagulant toxins that activate the coagulation cascade and cause venom-induced consumptive coagulopathy (VICC). We developed a semi-mechanistic model of the clotting cascade in order to explore the effects of the procoagulant toxin from taipan venom on this system as well as the effects of antivenom. Simulations of the time course in the change of clotting factors were compared to data collected from taipan envenomed patients. The model accurately predicted the obser  ...[more]

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