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Coletti2020 - QSP model of prostate cancer immunotherapy

ABSTRACT: This model is based on the publication: Coletti R, Leonardelli L, Parolo S, Marchetti L. A QSP model of prostate cancer immunotherapy to identify effective combination therapies. Sci Rep. 2020 Jun 3;10(1):9063. doi: 10.1038/s41598-020-65590-0 Comment: Eq. 3 - no listed species "R", therefore based on Eq. 1 and 2, R_2 used instead. Eq. 12 - no listed parameter "a_Df" in Table S1, a_Dc used based on parameter description. Curation Comment: Simulations are not reproducing manuscript plots. Matlab code is available (Supplementary File 2 of the manuscript publication) but has not been tested, so would be worth reattempting model curation.

DISEASE(S): Prostate Cancer

SUBMITTER: Emilia Chen

PROVIDER: MODEL2109110002 | BioModels | 2021-09-11

REPOSITORIES: BioModels

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A QSP model of prostate cancer immunotherapy to identify effective combination therapies.

Coletti Roberta R Leonardelli Lorena L Parolo Silvia S Marchetti Luca L

Scientific reports 20200603 1

Immunotherapy, by enhancing the endogenous anti-tumor immune responses, is showing promising results for the treatment of numerous cancers refractory to conventional therapies. However, its effectiveness for advanced castration-resistant prostate cancer remains unsatisfactory and new therapeutic strategies need to be developed. To this end, systems pharmacology modeling provides a quantitative framework to test in silico the efficacy of new treatments and combination therapies. In this paper we ...[more]

PMID: 32493951

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