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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of Staphylococcus aureus treated with tigecycline to determine the effect of the expression of virulence factors in biofilm-associated cells

ABSTRACT: Data is also available from BuG@Sbase

ORGANISM(S): Staphylococcus aureus

SUBMITTER:

PROVIDER: E-BUGS-81 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Influence of tigecycline on expression of virulence factors in biofilm-associated cells of methicillin-resistant Staphylococcus aureus.

Smith Karen K Gould Katherine A KA Ramage Gordon G Gemmell Curtis G CG Hinds Jason J Lang Sue S

Antimicrobial agents and chemotherapy 20091026 1

Methicillin-resistant Staphylococcus aureus (MRSA) infections are complicated by the ability of the organism to grow in surface-adhered biofilms on a multitude of abiotic and biological surfaces. These multicellular communities are notoriously difficult to eradicate with antimicrobial therapy. Cells within the biofilm may be exposed to a sublethal concentration of the antimicrobial due to the metabolic and phenotypic diversity of the biofilm-associated cells or the protection offered by the biof ...[more]

PMID: 19858261

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