Transcription profiling of human rheumatoid arthritis patients derived synovial fibroblasts - using boolean network models for extracellular matrix formation

ABSTRACT: Background ; Rheumatoid arthritis (RA) is a chronic inflammatory disease, characterized by joint destruction and perpetuated by the synovial membrane (SM). In the inflamed SM, activated synovial fibroblasts (SFB) form the major cell type promoting development and progression of the disease by an abnormal expression/secretion of pro-inflammatory cytokines, tissue-degrading enzymes resulting in a predominant degradation of the extra-cellular matrix (ECM), and collagens causing joint fibrosis. We developed a new procedure, based on human knowledge and formal concept analysis (FCA), to simulate and analyze the temporal behaviour of regulatory and signaling networks. It was applied to a regulatory network (containing 18 genes from 5 functional groups) representing ECM formation and destruction

ORGANISM(S): Homo sapiens

SUBMITTER: René Huber 

PROVIDER: E-GEOD-13837 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress