Multi-tissue, selective PPARγ modulation of insulin sensitivity and metabolic pathways in obese rats

ABSTRACT: We characterized the insulin sensitivity and multi-tissue gene expression profiles of lean and insulin resistant, obese Zucker rats untreated or treated with one of four PPARγ ligands (pioglitazone, rosiglitazone, troglitazone, and AG035029). We analyzed the transcriptional profiles of adipose tissue, skeletal muscle, and liver from the rats and determined whether ligand insulin-sensitizing potency was related to ligand-induced alteration of functional pathways. Ligand treatments improved insulin sensitivity in obese rats, albeit to varying degrees. Male Zucker fatty (fa/fa) and lean (fa/+) rats (Charles River, Wilmington, MA) were received at 6 weeks of age. Fatty rats were weight-matched upon arrival and randomly divided into one of five experimental groups. The fatty rat groups varied

ORGANISM(S): Rattus norvegicus

SUBMITTER: Gene Hsiao 

PROVIDER: E-GEOD-21329 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress