Gene expression change in the cerebellum and prefrontal cortex of depression rats

ABSTRACT: The depressive-like behavior in animals is usually assessed by standardized behavioral tests such as the forced swimming test. However, the findings of these tests may be affected by individual variability among animals, which may hinder the discovery of genes responsible for depression. Few reports have showed the influence of individual variability in identifying the genes associated with depressive-like behavior. In this study, we measured the immobility ratio (% immobility in 5 min) in the forced swimming test in 106 male Wistar rats. According to the distribution of individual immobility ratio, the rats were divided into three groups: the control group with immobility ratio -1 to +1 standard deviation (SD) from the mean, the depressive group with immobility ratio +1 to +2 SD above the

ORGANISM(S): Rattus norvegicus

SUBMITTER: Yuta Yamamoto 

PROVIDER: E-GEOD-63377 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress