Using Polygenic Hazard Scores to Predict Age at Onset of Alzheimer's Disease in Nordic Populations.

ABSTRACT:

Background

Polygenic hazard scores (PHS) estimate age-dependent genetic risk of late-onset Alzheimer's disease (AD), but there is limited information about the performance of PHS on real-world data where the population of interest differs from the model development population and part of the model genotypes are missing or need to be imputed.

Objective

The aim of this study was to estimate age-dependent risk of late-onset AD using polygenic predictors in Nordic populations.

Methods

We used Desikan PHS model, based on Cox proportional hazards assumption, to obtain age-dependent hazard scores for AD from individual genotypes in the Norwegian DemGene cohort (n = 2,772). We assessed the risk discrimination and calibration of Desikan model and extended it by adding new geno

SUBMITTER: Motazedi E 

PROVIDER: S-EPMC10022308 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature