Associating broad and clinically defined polygenic scores for depression with depression-related phenotypes.

ABSTRACT: Twin studies indicate that 30-40% of the disease liability for depression can be attributed to genetic differences. Here, we assess the explanatory ability of polygenic scores (PGS) based on broad- (PGS_BD) and clinical- (PGS_MDD) depression summary statistics from the UK Biobank in an independent sample of adults (N = 210; 100% European Ancestry) who were extensively phenotyped for depression and related neurocognitive traits (e.g., rumination, emotion regulation, anhedonia, and resting frontal alpha asymmetry). The UK Biobank-derived PGS_BD had small associations with MDD, depression severity, anhedonia, cognitive reappraisal, brooding, and suicidal ideation but only the association with suicidal ideation remained statistically significant after correcting f

SUBMITTER: McGeary JE 

PROVIDER: S-EPMC10121555 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature