The impact of metformin on survival in diabetes patients with operable colorectal cancer: A nationwide retrospective cohort study.

ABSTRACT:

Objective

To investigate the impact of metformin on survival of diabetic patients following surgery for colorectal cancer (CRC).

Methods

This was a retrospective cohort study. From Taiwan's population-based National Health Insurance Research Database (NHIRD) we identified 12,512 patients with CRC and type II diabetes who underwent curative surgery between 2000 and 2012. Of these, 6222 patients were included in a matched cohort. Using Cox regression models with time-dependent covariates we examined the impact of metformin on survival.

Results

Average duration of follow-up was 49 and 54 months for metformin users and non-users, respectively. Cox proportional hazard model showed that metformin was associated with 5-year overall survival benefit (Hazard ratio, 0.23 [95% C

SUBMITTER: Chu PT 

PROVIDER: S-EPMC10127213 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature