Dataset Information
The impact of metformin on survival in diabetes patients with operable colorectal cancer: A nationwide retrospective cohort study.
Ontology highlight
ABSTRACT: Objective
To investigate the impact of metformin on survival of diabetic patients following surgery for colorectal cancer (CRC).Methods
This was a retrospective cohort study. From Taiwan's population-based National Health Insurance Research Database (NHIRD) we identified 12,512 patients with CRC and type II diabetes who underwent curative surgery between 2000 and 2012. Of these, 6222 patients were included in a matched cohort. Using Cox regression models with time-dependent covariates we examined the impact of metformin on survival.Results
Average duration of follow-up was 49 and 54 months for metformin users and non-users, respectively. Cox proportional hazard model showed that metformin was associated with 5-year overall survival benefit (Hazard ratio, 0.23 [95% CI, 0.20-0.26]) and inverse association with risk of liver metastasis (Hazard ratio, 0.79 [95% CI, 0.68-0.93]).Conclusions
Metformin was associated with a survival benefit in diabetic patients with CRC following surgery, and an inverse association with risk of liver metastases suggesting a potential anti-tumorigenic effect.
SUBMITTER: Chu PT
PROVIDER: S-EPMC10127213 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
The impact of metformin on survival in diabetes patients with operable colorectal cancer: A nationwide retrospective cohort study.
The Journal of international medical research 20230401 4
<h4>Objective</h4>To investigate the impact of metformin on survival of diabetic patients following surgery for colorectal cancer (CRC).<h4>Methods</h4>This was a retrospective cohort study. From Taiwan's population-based National Health Insurance Research Database (NHIRD) we identified 12,512 patients with CRC and type II diabetes who underwent curative surgery between 2000 and 2012. Of these, 6222 patients were included in a matched cohort. Using Cox regression models with time-dependent covar ...[more]