Retinal Aging Transcriptome and Cellular Landscape in Association With the Progression of Age-Related Macular Degeneration.

ABSTRACT:

Purpose

Age is the main risk factor for age-related macular degeneration (AMD), a leading cause of blindness in the elderly, with limited therapeutic options.

Methods

Here, we analyze the transcriptomic characteristics and cellular landscape of the aging retinas from controls and patients with AMD.

Results

We identify the aging genes in the neural retina, which are associated with innate immune response and inflammation. Deconvolution analysis reveals that the estimated proportions of M2 macrophages are significantly increased with both age and AMD severity. Moreover, we find that proportions of Müller glia are significantly increased only with age but not with AMD severity. Several genes associated with both age and AMD severity, particularly C1s and MR1, are strong

SUBMITTER: Wang JH 

PROVIDER: S-EPMC10148661 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature