Dynamic cerebral autoregulation during step-wise increases in blood pressure during anaesthesia: A nonrandomised interventional trial.

ABSTRACT:

Background

Classically, cerebral autoregulation (CA) entails cerebral blood flow (CBF) remaining constant by cerebrovascular tone adapting to fluctuations in mean arterial pressure (MAP) between ∼60 and ∼150 mmHg. However, this is not an on-off mechanism; previous work has suggested that vasomotor tone is proportionally related to CA function. During propofol-based anaesthesia, there is cerebrovascular vasoconstriction, and static CA remains intact. Sevoflurane-based anaesthesia induces cerebral vasodilation and attenuates CA dose-dependently. It is unclear how this translates to dynamic CA across a range of blood pressures in the autoregulatory range.

Objective

The aim of this study was to quantify the effect of step-wise increases in MAP between 60 and 100 mmHg, using phen

SUBMITTER: van den Dool REC 

PROVIDER: S-EPMC10155696 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature