Development and validation of a selenium metabolism regulators associated prognostic model for hepatocellular carcinoma.

ABSTRACT:

Background

Selenium metabolism has been implicated in human health. This study aimed to identify a selenium metabolism regulator-based prognostic signature for hepatocellular carcinoma (HCC) and validate the role of INMT in HCC.

Methods

Transcriptome sequencing data and clinical information related to selenium metabolism regulators in TCGA liver cancer dataset were analysed. Next, a selenium metabolism model was constructed by multiple machine learning algorithms, including univariate, least absolute shrinkage and selection operator, and multivariate Cox regression analyses. Then, the potential of this model for predicting the immune landscape of different risk groups was evaluated. Finally, INMT expression was examined in different datasets. After knockdown of INMT, cell pr

SUBMITTER: Sun H 

PROVIDER: S-EPMC10197375 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature