Causal effects of gut microbiota on sepsis: a two-sample Mendelian randomization study.

ABSTRACT:

Background

Recent studies had provided evidence that the gut microbiota is associated with sepsis. However, the potential causal relationship remained unclear.

Methods

The present study aimed to explore the causal effects between gut microbiota and sepsis by performing Mendelian randomization (MR) analysis utilizing publicly accessible genome-wide association study (GWAS) summary-level data. Gut microbiota GWAS (N = 18,340) were obtained from the MiBioGen study and GWAS-summary-level data for sepsis were gained from the UK Biobank (sepsis, 10,154 cases; 452,764 controls). Two strategies were used to select genetic variants, i.e., single nucleotide polymorphisms (SNPs) below the locus-wide significance level (1 × 10^-5) and the genome-wide statistical signifi

SUBMITTER: Chen JH 

PROVIDER: S-EPMC10206031 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature