Mendelian randomization analyses of smoking and Alzheimer's disease in Chinese and Japanese populations.

ABSTRACT:

Background

Previous epidemiological studies have reported controversial results on the relationship between smoking and Alzheimer's disease (AD). Therefore, we sought to assess the association using Mendelian randomization (MR) analysis.

Methods

We used single nucleotide polymorphisms (SNPs) associated with smoking quantity (cigarettes per day, CPD) from genome-wide association studies (GWAS) of Japanese population as instrumental variables, then we performed two-sample MR analysis to investigate the association between smoking and AD in a Chinese cohort (1,000 AD cases and 500 controls) and a Japanese cohort (3,962 AD cases and 4,074 controls), respectively.

Results

Genetically higher smoking quantity showed no statistical causal association with AD risk (the inverse

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC10213305 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature