Herpesvirus infections and Alzheimer's disease: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that herpesvirus infection increased the risk of Alzheimer's disease (AD), but it is unclear whether the association is causal. The aim of the present study is to evaluate the causal relationship between four herpesvirus infections and AD.

Methods

We performed a two-sample Mendelian randomization analysis to investigate association of four active herpesvirus infections with AD using summary statistics from genome-wide association studies. The four herpesvirus infections (i.e., chickenpox, shingles, cold sores, mononucleosis) are caused by varicella-zoster virus, herpes simplex virus type 1, and Epstein-Barr virus (EBV), respectively. A large summary statistics data from International Genomics of Alzheimer's Project was used in

SUBMITTER: Huang SY 

PROVIDER: S-EPMC8464096 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature