Identification of prognostic hub genes and therapeutic targets for selenium deficiency in chicks model through transcriptome profiling.

ABSTRACT: Selenium deficiency is a prevalent micronutrient deficiency that poses a major health concern worldwide. This study aimed to shed light on the molecular mechanisms underlying selenium deficiency using a chick model. Chickens were divided into control and selenium deficient groups. Plasma samples were collected to measure selenium concentration and transcriptome analyse were performed on oviduct samples. The results showed that selenium deficiency led to a significant reduction in plasma selenium levels and altered the expression of 10,266 differentially expressed genes (DEGs). These DEGs primarily regulated signal transduction and cell motility. The molecular function includes GTPase regulatory activity, and KEGG pathway analysis showed that they were mainly involved in the signal transduc

SUBMITTER: Lingamgunta LK 

PROVIDER: S-EPMC10226025 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature