Evaluation of Immunohistochemical Expression of Heparanase in Helicobacter pylori-Associated Chronic Gastritis.

ABSTRACT:

Background

Chronic gastritis (CG) is a very common disease. More than half of the worldwide population suffers from symptoms of CG. This disease has received great attention since the discovery of H. pylori as the most important cause of CG. Symptoms experienced by patients with CG are attributed to H. pylori-induced inflammatory reactions. Heparanase (HPSE) is a mammalian β-endoglucoronidase. In inflammation; HPSE degrades and remodels the extracellular matrix's heparan sulfate polysaccharide chains liberating heparan sulfate-bound cytokines and chemokines, HPSE also facilitates movement of inflammatory cells.

Aims

This study aimed to detect the function of HPSE in CG by correlating levels of HPSE expression with histopathological features of CG, including

SUBMITTER: Ahmed SFM 

PROVIDER: S-EPMC10392192 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature