Brain networks and epilepsy development in patients with Alzheimer disease.

ABSTRACT:

Introduction

This study aimed to investigate the association between brain networks and epilepsy development in patients with Alzheimer disease (AD).

Methods

We enrolled patients newly diagnosed with AD at our hospital who underwent three-dimensional T1-weighted magnetic resonance imaging at the time of AD diagnosis and included healthy controls. We obtained the cortical, subcortical, and thalamic nuclei structural volumes using FreeSurfer and applied graph theory to obtain the global brain network and intrinsic thalamic network based on the structural volumes using BRAPH.

Results

We enrolled 25 and 56 patients with AD with and without epilepsy development, respectively. We also included 45 healthy controls. The global brain network differed between the patients with

SUBMITTER: Lee DA 

PROVIDER: S-EPMC10454249 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature