Dataset Information

A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [¹⁸F]PFSB and [¹⁸F]MFSB.

ABSTRACT: A method to detect and quantify aggregated α-synuclein (αSYN) fibrils in vivo would drastically impact the current understanding of multiple neurodegenerative diseases, revolutionizing their diagnosis and treatment. Several efforts have produced promising scaffolds, but a notable challenge has hampered the establishment of a clinically successful αSYN positron emission tomography (PET) tracer: the requirement of high selectivity over the other misfolded proteins amyloid β (Aβ) and tau. By designing and screening a library of 2-styrylbenzothiazoles based on the selective fluorescent probe RB1, this study aimed at developing a selective αSYN PET tracer. [³H]PiB competition binding assays identified PFSB (K_i = 25.4 ± 2.3 nM) and its less lipop

SUBMITTER: Di Nanni A

PROVIDER: S-EPMC10468942 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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Dataset Information

A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [¹⁸F]PFSB and [¹⁸F]MFSB.

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Dataset Information

A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [18F]PFSB and [18F]MFSB.

OmicsDI is part of the ELIXIR infrastructure

Tweets

A Fluorescent Probe as a Lead Compound for a Selective α-Synuclein PET Tracer: Development of a Library of 2-Styrylbenzothiazoles and Biological Evaluation of [¹⁸F]PFSB and [¹⁸F]MFSB.