Short-term intensive fasting enhances the immune function of red blood cells in humans.

ABSTRACT:

Background

Fasting is known to influence the immune functions of leukocytes primarily by regulating their mobilization and redistribution between the bone marrow and the peripheral tissues or circulation, in particular via relocalization of leukocytes back in the bone marrow. However, how the immune system responds to the increased risk of invasion by infectious pathogens with fewer leukocytes in the peripheral blood during fasting intervention remains an open question.

Results

We used proteomic, biochemical and flow cytometric tools to evaluate the impact of short-term intensive fasting (STIF), known as beego, on red blood cells by profiling the cells from the STIF subjects before and after 6 days of fasting and 6 days of gradual refeeding. We found that STIF, by triggering

SUBMITTER: Fang Y 

PROVIDER: S-EPMC10469874 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature