Reduced cortical cerebral blood flow in antipsychotic-free first-episode psychosis and relationship to treatment response.

ABSTRACT:

Background

Altered cerebral blood flow (CBF) has been found in people at risk for psychosis, with first-episode psychosis (FEP) and with chronic schizophrenia (SCZ). Studies using arterial spin labelling (ASL) have shown reduction of cortical CBF and increased subcortical CBF in SCZ. Previous studies have investigated CBF using ASL in FEP, reporting increased CBF in striatum and reduced CBF in frontal cortex. However, as these people were taking antipsychotics, it is unclear whether these changes are related to the disorder or antipsychotic treatment and how they relate to treatment response.

Methods

We examined CBF in FEP free from antipsychotic medication (N = 21), compared to healthy controls (N = 22). Both absolute and relative-to-global CBF were assessed.

SUBMITTER: Selvaggi P 

PROVIDER: S-EPMC10476071 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature