Lipidomic analysis of differently prepared platelet concentrates in additive solution during storage.

ABSTRACT:

Background

Structural and biochemical changes in stored platelets are influenced by collection and processing methods. Lesions may appear during platelet concentrate storage, some of which may be involved in adverse transfusion reactions. The preparation and storage of platelet concentrates (PC) may modify and even damage the lipid mediator content. The aim of this study was to investigate the lipidomic profile identified in the supernatants of PCs according to processing and storage conditions, both after leukocyte filtration and contained in platelet additive solution (PAS), comparing single donor apheresis (SDA) products with pooled buffy coat (BC) products.

Materials and methods

We investigated the accumulation of various lipid mediators including lysophospholipids (LP)

SUBMITTER: Duchez AC 

PROVIDER: S-EPMC10497391 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature