Platelet concentrates in platelet additive solutions generate less complement activation products during storage than platelets stored in plasma.

ABSTRACT:

Background

Platelet transfusions can be associated with adverse reactions, such as febrile non-haemolytic transfusion reaction (FNHTR). It has been suggested that damage-associated molecular patterns (DAMP) and complement play a role in FNHTR. This study investigated the nature of DAMPs and complement activation products contained in platelet concentrates during storage, with a specific focus on different platelet storage solutions.

Materials and methods

Buffy coats (BC) from healthy donors were pooled (15 BC per pool) and divided into three groups of the same volume. After addition of different storage solutions (plasma, platelet additive solutions [PAS]-C or PAS-E; n=6 for each group), BC pools were processed to platelet concentrates (PC). Leukoreduced PCs were stored on a

SUBMITTER: de Wit YES 

PROVIDER: S-EPMC10072994 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature