Genetic Insights into Intestinal Microbiota and Risk of Infertility: A Mendelian Randomization Study.

ABSTRACT:

Background

The interaction between intestinal microbiota and infertility is less researched. This study was performed to investigate the causal association between gut microbiota and infertility.

Methods

In this two-sample Mendelian randomization (MR) study, genetic variants of intestinal microbiota were obtained from the MiBioGen consortium, which included 18,340 individuals. Inverse variance weighting (IVW), MR-Egger, weighted median, maximum likelihood, MR Robust adjusted profile score, MR Pleiotropy residual sum, and outlier (MR-PRESSO) methods were used to explore the causal links between intestinal microbiota and infertility. The MR-Egger intercept term and the global test from the MR-PRESSO estimator were used to assess the horizontal pleiotropy. The Cochran Q test wa

SUBMITTER: Zhang F 

PROVIDER: S-EPMC10538041 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature