Insights into Modifiable Risk Factors of Infertility: A Mendelian Randomization Study.

ABSTRACT:

Objective

Observational studies have linked lifestyle, diet, obesity, and biochemical measures with infertility. Whether this association is causal is unclear. We sought to identify the causal relationship between modifiable risk factors with infertility.

Methods

Using single-nucleotide polymorphisms (SNPs) as a genetic instrument variable, we carried out a two-sample Mendelian randomization (MR) analysis to estimate the causal effects for 22 modifiable risk factors on female infertility (6481 cases; 75,450 participants) and male infertility (680 cases; 73,479 participants).

Results

The results of the study showed that BMI (OR: 1.24, 95% CI (1.09, 1.40)), body fat percentage (OR: 1.73, 95% CI (1.13, 2.64)), and alcohol consumption (OR: 6.57,95% CI (1.2, 36.14)) are as

SUBMITTER: Xu W 

PROVIDER: S-EPMC9572512 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature