Genetic insights into the gut microbiota and risk of psoriasis: a bidirectional mendelian randomization study.

ABSTRACT:

Background

Growing evidence indicates a potential association between the gut microbiome and psoriasis. Nevertheless, the precise nature of these associations and whether they constitute causal relationships remain unclear.

Methods

A rigorous bidirectional two-sample Mendelian randomization study was undertaken to establish a putative causal link between gut microbiota and psoriasis. We drew upon publicly available datasets containing summary statistics from GWAS to accomplish this. Utilizing various analytical techniques, including inverse variance weighting, MR-Egger, weighted median, weighted model, and MR-PRESSO, we sought to validate the putative causal association between gut microbiota and psoriasis. A reverse Mendelian randomization analysis was conducted to further

SUBMITTER: Qian M 

PROVIDER: S-EPMC11331342 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature