Revealing a causal relationship between gut microbiota and lung cancer: a Mendelian randomization study.

ABSTRACT:

Background

The gut microbiota has been found to be associated with the risk of lung cancer. However, its causal relationship with various types of lung cancer remains unclear.

Methods

We conducted a Mendelian randomization (MR) study using the largest genome-wide association analysis of gut microbiota data to date from the MiBioGen consortium, with pooled statistics for various types of lung cancer from the Transdisciplinary Research in Cancer of the Lung, the International Lung Cancer Consortium, and FinnGen Consortium R7 release data. Inverse variance weighted, weighted model, MR-Egger regression, and weighted median were adapted to assess the causal relationship between gut microbiota and various types of lung cancer. Sensitivity analysis was used to test for the presence

SUBMITTER: Li Y 

PROVIDER: S-EPMC10565354 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature