Causal relationships between blood lipids and major psychiatric disorders: Univariable and multivariable mendelian randomization analysis.

ABSTRACT:

Background

Whether the positive associations of blood lipids with psychiatric disorders are causal is uncertain. We conducted this two-sample Mendelian randomization (MR) analysis to comprehensively investigate associations of blood lipids with psychiatric disorders.

Methods

Univariable and multivariable models were established for MR analyses. Inverse variance-weighted (IVW) MR was employed as the main approach; weighted median and MR-Egger were used as sensitivity analysis methods. The possibility of violating MR assumptions was evaluated utilizing several sensitivity analyses, including heterogeneity statistics, horizontal pleiotropy statistics, single SNP analysis, leave-one-out analysis and MR-PRESSO analysis. As instrumental variables, we screened 362 independent singl

SUBMITTER: Li B 

PROVIDER: S-EPMC10585856 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature